Osteosarcoma of bone in apatient with primary hyperparathyroidism: a case report

J Bone Miner Res. 2003 Jan;18(1):163-6. doi: 10.1359/jbmr.2003.18.1.163.


A 69-year-old woman was diagnosed with a malignant tumor of the right proximal femur. She had primary hyperparathyroidism and chronic elevation of parathyroid hormone levels (PTH > 1,000 pg/ml). She underwent resection of the bone lesion; histological analysis showed a high-grade fibroblastic osteosarcoma. In addition, she underwent curative resection of a large left superior parathyroid adenoma. To our knowledge, this is the third reported clinical case of osteosarcoma arising in association with hyperparathyroidism.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / complications
  • Aged
  • Female
  • Femoral Neoplasms / complications*
  • Femoral Neoplasms / pathology
  • Humans
  • Hyperparathyroidism / complications*
  • Osteosarcoma / complications*
  • Osteosarcoma / pathology
  • Parathyroid Hormone / blood
  • Parathyroid Neoplasms / complications


  • Parathyroid Hormone