Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer

J Clin Invest. 2003 Jan;111(1):31-3. doi: 10.1172/JCI17492.
No abstract available

Publication types

  • Comment
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Bronchi / drug effects*
  • Carcinogens
  • Enzyme Activation
  • Epithelial Cells / drug effects*
  • Humans
  • Lung Neoplasms / etiology*
  • Lung Neoplasms / pathology
  • Nicotine / adverse effects*
  • Nitrosamines / adverse effects
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-akt
  • Receptors, Nicotinic / biosynthesis*

Substances

  • Carcinogens
  • Nitrosamines
  • Proto-Oncogene Proteins
  • Receptors, Nicotinic
  • Nicotine
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • N'-nitrosonornicotine