Border-cell migration: the race is on

Nat Rev Mol Cell Biol. 2003 Jan;4(1):13-24. doi: 10.1038/nrm1006.


The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology*
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / embryology*
  • Epithelial Cells / cytology*
  • Female
  • Gene Expression Regulation, Developmental
  • Ovary / cytology*
  • Signal Transduction / physiology