Solvable senescence model showing a mortality plateau

Phys Rev Lett. 2002 Dec 31;89(28 Pt 1):288103. doi: 10.1103/PhysRevLett.89.288103. Epub 2002 Dec 27.

Abstract

We present some analytic results for the steady states of the Penna model of senescence, generalized to allow genetically identical individuals to die at different ages via an arbitrary survival function. Modeling this with a Fermi function (of modest width) we obtain a clear mortality plateau late in life: something that has so far eluded explanation within such mutation accumulation models. This suggests that factors causing variable mortality within genetically identical subpopulations, which include environmental effects, may be essential to understanding the mortality plateau seen in many real species.