Termination of translation: interplay of mRNA, rRNAs and release factors?

EMBO J. 2003 Jan 15;22(2):175-82. doi: 10.1093/emboj/cdg017.


Termination of translation in eukaryotes has focused recently on functional anatomy of polypeptide chain release factor, eRF1, by using a variety of different approaches. The tight correlation between the domain structure and different functions of eRF1 has been revealed. Independently, the role of prokaryotic RF1/2 in GTPase activity of RF3 has been deciphered, as well as RF3 function itself.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Codon, Terminator
  • GTP Phosphohydrolases / metabolism
  • Humans
  • Models, Genetic
  • Models, Molecular
  • Molecular Sequence Data
  • Peptide Termination Factors / chemistry
  • Peptide Termination Factors / genetics
  • Peptide Termination Factors / metabolism*
  • Protein Biosynthesis*
  • Protein Conformation
  • RNA, Messenger / metabolism*
  • RNA, Ribosomal / metabolism*


  • Codon, Terminator
  • ETF1 protein, human
  • Peptide Termination Factors
  • RNA, Messenger
  • RNA, Ribosomal
  • GTP Phosphohydrolases