The clinical significance of major depression following mild traumatic brain injury

Psychosomatics. 2003 Jan-Feb;44(1):31-7. doi: 10.1176/appi.psy.44.1.31.


Objective: The authors assessed the association of major depression with behavioral outcome following mild traumatic brain injury.

Method: Consecutive patients with mild traumatic brain injury (N=170) were assessed for major depression. Those with major depression were compared with those without on self-report measures of psychosocial dysfunction, psychological distress, and postconcussive symptoms in addition to examiner-rated neurobehavioral disturbance.

Results: Major depression was seen in 15.3% (N=26) of the subjects after traumatic brain injury, and these individuals showed subjective and objective evidence of poorer outcome.

Conclusions: Major depression is associated with poor outcome across multiple domains. This study highlights the need for the early diagnosis and prompt treatment of major depression following mild traumatic brain injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Brain Injuries / psychology*
  • Chi-Square Distribution
  • Depression / epidemiology
  • Depression / psychology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Surveys and Questionnaires