Chorioamnionitis and brain injury

Clin Perinatol. 2002 Dec;29(4):603-21. doi: 10.1016/s0095-5108(02)00058-1.


The limited available evidence supports a strong association of chorioamnionitis with neonatal encephalopathy and CP in the term infant. The association of chorioamnionitis with depressed Apgar scores or neonatal seizures and with CP is equivocal in the preterm infant. Different study results may be related to differences in study populations, perhaps specifically to differences in susceptibility by stages of neurologic development as well as differences in gene frequencies associated with inflammation and thrombophilia. We require further understanding of the normal roles of cytokines in brain development, pregnancy, and inflammatory homeostasis before clinical interventions directed at cytokines, their receptors, or the inflammatory process are considered.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Birth Injuries / microbiology*
  • Brain Injuries / congenital*
  • Brain Injuries / microbiology*
  • Cerebral Palsy / congenital*
  • Cerebral Palsy / microbiology*
  • Chorioamnionitis / complications*
  • Chorioamnionitis / diagnosis
  • Chorioamnionitis / microbiology
  • Chorioamnionitis / prevention & control
  • Female
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Hypoxia-Ischemia, Brain / congenital*
  • Hypoxia-Ischemia, Brain / microbiology*
  • Infant, Newborn
  • Infant, Premature, Diseases / microbiology
  • Inflammation
  • Mass Screening / methods
  • Pregnancy
  • Risk Factors
  • Sensitivity and Specificity


  • Anti-Bacterial Agents