Advances in postnatal neuroimaging: relevance to pathogenesis and treatment of brain injury

Clin Perinatol. 2002 Dec;29(4):827-56. doi: 10.1016/s0095-5108(02)00049-0.


The human brain is susceptible to a wide variety of insults. The permanent residua of these abnormalities are represented in dysfunction of one or more areas of neurodevelopment. A full understanding of normal brain development, mechanisms of brain injury, and consequences for subsequent brain development is required to determine which infants are at risk for neurodevelopmental handicap, and to monitor the effects of new treatments and management regimens designed to prevent these disabilities. Advanced magnetic resonance techniques, such as quantitative morphometric magnetic resonance techniques, diffusion-weighted magnetic resonance techniques, and magnetic resonance spectroscopy applied to the study of early human brain development have given us a better understanding of the pathophysiologic mechanisms of brain injury and its effects on subsequent brain development. Magnetic resonance imaging has provided an invaluable tool for the study of the fetal and newborn brain in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Asphyxia Neonatorum / diagnosis*
  • Asphyxia Neonatorum / etiology
  • Asphyxia Neonatorum / therapy
  • Birth Injuries / diagnosis*
  • Birth Injuries / etiology
  • Birth Injuries / therapy
  • Brain / growth & development
  • Brain Injuries / congenital*
  • Brain Injuries / diagnosis*
  • Brain Injuries / therapy
  • Cerebral Hemorrhage / congenital
  • Cerebral Hemorrhage / diagnosis
  • Cerebral Hemorrhage / therapy
  • Cerebral Infarction / congenital
  • Cerebral Infarction / diagnosis
  • Cerebral Infarction / therapy
  • Humans
  • Hypoxia-Ischemia, Brain / congenital*
  • Hypoxia-Ischemia, Brain / diagnosis*
  • Hypoxia-Ischemia, Brain / therapy
  • Infant, Newborn
  • Leukomalacia, Periventricular / diagnosis
  • Leukomalacia, Periventricular / etiology
  • Leukomalacia, Periventricular / therapy
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / trends
  • Magnetic Resonance Spectroscopy / methods
  • Postnatal Care / methods*
  • Postnatal Care / trends
  • Prenatal Care / methods
  • Prenatal Care / trends