Hold tight (but not too tight) to get it right: accurate bypass of an 8-oxoguanine lesion by DNA polymerase beta

Structure. 2003 Jan;11(1):1-2. doi: 10.1016/s0969-2126(02)00917-6.

Abstract

Crystal structures of DNA polymerase beta encountering an 8-oxoguanine lesion show how the polymerase selects an otherwise unfavorable conformation of a damaged template base to enable error-free bypass.

Publication types

  • Comment
  • News

MeSH terms

  • Animals
  • DNA Damage*
  • DNA Polymerase beta / chemistry*
  • DNA Polymerase beta / metabolism
  • DNA Replication
  • Guanine / analogs & derivatives*
  • Guanine / chemistry*
  • Guanine / metabolism
  • Molecular Structure
  • Nucleic Acid Conformation
  • Protein Binding

Substances

  • 8-hydroxyguanine
  • Guanine
  • DNA Polymerase beta