Cell Polarity: Par6, aPKC and Cytoskeletal Crosstalk

Curr Opin Cell Biol. 2003 Feb;15(1):67-72. doi: 10.1016/s0955-0674(02)00005-4.

Abstract

Par6 and atypical protein kinase C are key players in the establishment of cell polarity. First discovered in Caenorhabditis elegans, the function of this protein complex is conserved in all multicellular organisms. Recent work is beginning to throw light on how it converts information generated by extracellular cues into intracellular asymmetry.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans Proteins
  • Cell Division / physiology
  • Cell Movement / physiology
  • Cell Polarity / physiology*
  • Cytoskeleton / metabolism*
  • Eukaryotic Cells / metabolism*
  • Eukaryotic Cells / ultrastructure
  • Humans
  • Intercellular Junctions / metabolism
  • Intercellular Junctions / ultrastructure
  • Macromolecular Substances
  • Protein Kinase C / metabolism*
  • Proteins / metabolism*

Substances

  • Caenorhabditis elegans Proteins
  • Macromolecular Substances
  • Proteins
  • par-6 protein, C elegans
  • PKC-3 protein
  • Protein Kinase C