Basal body/centriole Assembly and Continuity

Curr Opin Cell Biol. 2003 Feb;15(1):96-104. doi: 10.1016/s0955-0674(02)00017-0.

Abstract

The long-standing interest in centrioles and basal bodies stems from the evolutionary conservation of their structural design and from their dual mode of assembly (templated versus de novo), revealed by electron microscopic studies nearly four decades ago and unique for a subcellular organelle. Molecular dissection of the assembly pathway during the past few years has recently progressed, essentially through direct and reverse genetic approaches. These studies revealed essential roles for centrins and the gamma-, delta-, epsilon - and eta-tubulins in assembly or as specific signals for centriole duplication. Identification of further components of basal bodies and centrioles might help to unravel the two assembly pathways and their regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division / physiology
  • Centrioles / metabolism*
  • Centrioles / ultrastructure
  • Eukaryotic Cells / metabolism*
  • Eukaryotic Cells / ultrastructure
  • Evolution, Molecular
  • Humans
  • Phylogeny
  • Trimethoprim, Sulfamethoxazole Drug Combination / metabolism
  • Tubulin / metabolism

Substances

  • Tubulin
  • Trimethoprim, Sulfamethoxazole Drug Combination