Human immunodeficiency virus reverse transcriptase and protease sequence database

Nucleic Acids Res. 2003 Jan 1;31(1):298-303. doi: 10.1093/nar/gkg100.


The HIV reverse transcriptase and protease sequence database is an on-line relational database that catalogues evolutionary and drug-related sequence variation in the human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes, the molecular targets of antiretroviral therapy ( The database contains a compilation of nearly all published HIV RT and protease sequences, including submissions to GenBank, sequences published in journal articles and sequences of HIV isolates from persons participating in clinical trials. Sequences are linked to data about the source of the sequence, the antiretroviral drug treatment history of the person from whom the sequence was obtained and the results of in vitro drug susceptibility testing. Sequence data on two new molecular targets of HIV drug therapy--gp41 (cell fusion) and integrase--will be added to the database in 2003.

MeSH terms

  • Amino Acid Sequence
  • Anti-HIV Agents / therapeutic use
  • Databases, Protein*
  • Drug Design
  • Drug Resistance, Viral
  • Genetic Variation
  • HIV Infections / drug therapy*
  • HIV Protease / genetics*
  • HIV Protease Inhibitors / therapeutic use
  • HIV Reverse Transcriptase / antagonists & inhibitors
  • HIV Reverse Transcriptase / genetics*
  • HIV-1 / drug effects*
  • HIV-1 / isolation & purification
  • Humans
  • Mutation
  • Phenotype
  • Sequence Alignment
  • Sequence Analysis, Protein


  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • HIV Reverse Transcriptase
  • HIV Protease