Hypocholesterolemic effect of hot-water extract from mycelia of Cordyceps sinensis

Biol Pharm Bull. 2003 Jan;26(1):84-7. doi: 10.1248/bpb.26.84.


This study was conducted to investigate the hypocholesterolemic effect of the hot-water fraction (HW) from cultured mycelia of Cordyceps sinensis in a 5 l fermenter. The composition of HW was mainly carbohydrate (83.9%) and protein (11.8%) on a dry basis, and the carbohydrate of HW consisted of glucose, mannose, galactose, and arabinose in the molecular ratio of 1.0 : 0.8 : 0.5 : 0.1, respectively. In mice fed a cholesterol-free diet and those fed a cholesterol-enriched diet, body and liver weights were not significantly different from those of the controls. The serum total cholesterol (TC) of all mice groups administered HW (150 and 300 mg/kg/d, respectively) with the cholesterol-enriched diet decreased more than in the control group. Among the mice fed the cholesterol-enriched diet, HW also increased the high-density lipoprotein (HDL) cholesterol level, but decreased the very low-density lipoprotein plus low-density lipoprotein (VLDL+LDL) cholesterol level. The changes in HDL- and VLDL+LDL-cholesterol levels consequently decreased the atherogenic value. The results indicate that HW in rats administered a cholesterol-enriched diet decreased the plasma cholesterol level. The 300 mg/kg dose had a significant effect on the serum TC level.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anticholesteremic Agents / blood
  • Anticholesteremic Agents / isolation & purification
  • Anticholesteremic Agents / pharmacology*
  • Anticholesteremic Agents / therapeutic use
  • Cell Extracts / isolation & purification
  • Cell Extracts / pharmacology
  • Cordyceps / growth & development
  • Cordyceps / isolation & purification
  • Cordyceps / physiology*
  • Male
  • Mice
  • Mice, Inbred ICR
  • Mycelium / isolation & purification
  • Mycelium / physiology*
  • Water*


  • Anticholesteremic Agents
  • Cell Extracts
  • Water