Effect of berberine on bone mineral density in SAMP6 as a senile osteoporosis model

Biol Pharm Bull. 2003 Jan;26(1):110-1. doi: 10.1248/bpb.26.110.


The effects of berberine in senescence accelerated mice P6 (SAMP6) were investigated to learn whether the alkaloid affects bone mineral density (BMD). Oral administration of berberine (10 mg/kg/d) to male and female mice for 22 weeks resulted in an increase in BMD in both sexes. A decreased concentration of deoxypyridinoline (Dpd) in urine was only observed in female mice. There was no effect on body or tibia weight or on the concentration of procollagen type I carboxyterminal extension peptide (PICP) in serum.

Publication types

  • Comparative Study

MeSH terms

  • Aging / drug effects*
  • Aging / genetics
  • Aging / metabolism*
  • Animals
  • Berberine / chemistry
  • Berberine / pharmacology*
  • Berberine / therapeutic use
  • Bone Density / drug effects*
  • Bone Density / physiology
  • Disease Models, Animal*
  • Female
  • Hydrastis / chemistry
  • Male
  • Mice
  • Mice, Mutant Strains
  • Osteoporosis / drug therapy
  • Osteoporosis / genetics
  • Osteoporosis / metabolism*
  • Ranunculaceae / chemistry


  • Berberine