Vitamin D regulation of the renin-angiotensin system

J Cell Biochem. 2003 Feb 1;88(2):327-31. doi: 10.1002/jcb.10343.


The renin-angiotensin system (RAS) plays a central role in the regulation of blood pressure, electrolyte, and volume homeostasis. Epidemiological and clinical studies have long suggested an association of inadequate sunlight exposure or low serum 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] levels with high blood pressure and/or high plasma renin activity, but the mechanism is not understood. Our recent discovery that 1,25(OH)(2)D(3) functions as a potent negative endocrine regulator of renin gene expression provides some insights into the mechanism. The concept of vitamin D regulation of blood pressure through the RAS opens a new avenue to our understanding of the physiological functions of the vitamin D endocrine system, and provides a basis for exploring the potential use of vitamin D analogues in prevention and treatment of hypertension.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Gene Expression Regulation
  • Humans
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Renin / biosynthesis
  • Renin / genetics
  • Renin-Angiotensin System / drug effects*
  • Renin-Angiotensin System / genetics
  • Renin-Angiotensin System / physiology*
  • Signal Transduction / drug effects
  • Signal Transduction / immunology
  • Signal Transduction / physiology*
  • Vitamin D / analogs & derivatives
  • Vitamin D / metabolism*
  • Vitamin D / pharmacology


  • Vitamin D
  • Renin