HGF/SF-met signaling in the control of branching morphogenesis and invasion

J Cell Biochem. 2003 Feb 1;88(2):408-17. doi: 10.1002/jcb.10358.


Hepatocyte growth factor/Scatter factor (HGF/SF) is a multifunctional growth factor which can induce diverse biological events. In vitro, these include scattering, invasion, proliferation and branching morphogenesis. In vivo, HGF/SF is responsible for many processes during embryonic development and a variety of activities in adults, and many of these normal activities have been implicated in its role in tumorgenesis and metastasis. The c-Met receptor tyrosine kinase is the only known receptor for HGF/SF and mediates all HGF/SF induced biological activities. Upon HGF/SF stimulation, the c-Met receptor is tyrosine-phosphorylated which is followed by the recruitment of a group of signaling molecules and/or adaptor proteins to its cytoplasmic domain and its multiple docking sites. This action leads to the activation of several different signaling cascades that form a complete network of intra and extracellular responses. Different combinations of signaling pathways and signaling molecules and/or differences in magnitude of responses contribute to these diverse series of HGF/SF-Met induced activities and most certainly are influenced by cell type as well as different cellular environments. In this review, we focus on HGF/SF-induced branching morphogenesis and invasion, and bring together recent new findings which provide insight into how HGF/SF, via c-Met induces this response.

Publication types

  • Review

MeSH terms

  • Animals
  • Extracellular Matrix / metabolism
  • Hepatocyte Growth Factor / metabolism*
  • Humans
  • Morphogenesis*
  • Neoplasm Invasiveness*
  • Neoplasms / pathology
  • Protein-Tyrosine Kinases / metabolism
  • Proto-Oncogene Proteins c-met / metabolism
  • Signal Transduction / physiology*


  • Hepatocyte Growth Factor
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins c-met