Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3

Biochem J. 2003 Mar 1;370(Pt 2):391-6. doi: 10.1042/BJ20021935.


In the present paper, we report the identification of a new gene encoding a transmembrane protein of 520 amino acids, showing 22% amino acid identity with the extracellular domain of the interleukin (IL)-20 receptor. This gene, termed likely interleukin or cytokine receptor-2 ( LICR2 ), is located on chromosome 1, at 25 kb from the IL22R (IL-22 receptor) gene, and is constitutively expressed in most tissues. A chimaeric receptor, consisting of the extracellular domain of the IL-10 receptor alpha chain and the intracellular domain of LICR2, activated signal transducer and activator of transcription (STAT)1, STAT2, STAT3 and STAT5 upon IL-10 stimulation, in a Janus kinase 1-dependent manner. In contrast, none of the IL-10-related cytokines described so far could activate LICR2-transfected cells, suggesting that LICR2 is a signalling receptor for a new cytokine of the IL-10 family.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cloning, Molecular
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Interleukin-10
  • Janus Kinase 1
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Cytokine / genetics*
  • Receptors, Cytokine / metabolism
  • STAT1 Transcription Factor
  • STAT2 Transcription Factor
  • STAT3 Transcription Factor
  • Signal Transduction / physiology
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Transcription, Genetic / physiology


  • DNA-Binding Proteins
  • Receptors, Cytokine
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • STAT2 Transcription Factor
  • STAT2 protein, human
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Trans-Activators
  • Interleukin-10
  • Protein-Tyrosine Kinases
  • JAK1 protein, human
  • Janus Kinase 1

Associated data

  • GENBANK/AJ543330
  • GENBANK/AJ543331