Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

Biochem J. 2003 Mar 1;370(Pt 2):397-402. doi: 10.1042/BJ20021853.


Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport / genetics
  • Gene Deletion
  • Mice
  • Mice, Transgenic
  • Proteins / genetics*
  • Proteins / metabolism*
  • Selenium / metabolism*
  • Selenoprotein P
  • Selenoproteins


  • Proteins
  • Selenoprotein P
  • Selenoproteins
  • Selenium