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. 2003 Mar 1;370(Pt 2):397-402.
doi: 10.1042/BJ20021853.

Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

Lutz Schomburg  1 , Ulrich Schweizer, Bettina Holtmann, Leopold Flohé, Michael Sendtner, Josef Köhrle
Affiliations

Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

Lutz Schomburg et al. Biochem J. .

Abstract

Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.

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