Abstract
The superoxide dismutase mimetic EUK-8 has been reported to extend lifespan in the nematode Caenorhabditis elegans. However, in five trials administering EUK-8 in liquid culture with E. coli, and two trials using defined liquid medium, we observed no increase in C. elegans lifespan. Instead we saw a dose-dependent reduction of lifespan and fertility. We conclude that extension of C. elegans lifespan by EUK-8 may only occur under very particular culture conditions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Caenorhabditis elegans / drug effects*
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Caenorhabditis elegans / physiology
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Dose-Response Relationship, Drug
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Ethylenediamines / pharmacology*
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Fertility / drug effects
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Longevity / drug effects*
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Molecular Mimicry
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Organometallic Compounds / pharmacology*
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Superoxide Dismutase*
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Time Factors
Substances
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Ethylenediamines
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Organometallic Compounds
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N,N'-bis(salicylideneamino)ethane-manganese(II)
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Superoxide Dismutase