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. 2003 Jan 15;34(2):277-82.
doi: 10.1016/s0891-5849(02)01290-x.

No Increase in Lifespan in Caenorhabditis Elegans Upon Treatment With the Superoxide Dismutase Mimetic EUK-8

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No Increase in Lifespan in Caenorhabditis Elegans Upon Treatment With the Superoxide Dismutase Mimetic EUK-8

Michelle Keaney et al. Free Radic Biol Med. .

Abstract

The superoxide dismutase mimetic EUK-8 has been reported to extend lifespan in the nematode Caenorhabditis elegans. However, in five trials administering EUK-8 in liquid culture with E. coli, and two trials using defined liquid medium, we observed no increase in C. elegans lifespan. Instead we saw a dose-dependent reduction of lifespan and fertility. We conclude that extension of C. elegans lifespan by EUK-8 may only occur under very particular culture conditions.

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