Concentrations of interleukins, interferon, and C-reactive protein in stable and unstable angina pectoris

Am J Cardiol. 2003 Jan 15;91(2):133-6. doi: 10.1016/s0002-9149(02)03097-7.


We analyzed the concentrations of interleukins (IL)-6, IL-10, IL-12, and IL-18, interferon (IFN)-gamma, and high-sensitivity C-reactive protein (hsCRP) in 40 patients with unstable angina (UAP), 39 patients with stable angina (SAP), and 52 age- and gender-matched controls. Compared with the control group, IL-12 concentrations were significantly higher in both the SAP and UAP groups, especially in the UAP group, and the IL-18 concentrations tended to be higher in the UAP group. Conversely, IL-10 concentrations were significantly lower in the SAP and UAP groups. Both IL-6 and hsCRP concentrations were significantly higher in the UAP group. The levels of hsCRP were positively correlated with inflammatory or proinflammatory cytokines (IL-6, IL-12, and IL-18), and negatively correlated with anti-inflammatory cytokine (IL-10). Moreover, the levels of IL-12 were positively correlated with IL-18, and negatively correlated with IL-10, and the results revealed the T-helper 1 dominant state. These results suggested that the inflammatory response was strongly associated with coronary atherosclerosis and angina pectoris, and that the T-helper 1 dominance may play an important role in these diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angina Pectoris / blood*
  • Angina, Unstable / blood*
  • C-Reactive Protein / metabolism*
  • Cytokines / blood*
  • Female
  • Humans
  • Interferon-gamma / blood
  • Interleukin-10 / blood
  • Interleukin-12 / blood
  • Interleukin-18 / blood
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • T-Lymphocytes, Helper-Inducer / metabolism*


  • Cytokines
  • Interleukin-18
  • Interleukin-6
  • Interleukin-10
  • Interleukin-12
  • Interferon-gamma
  • C-Reactive Protein