Restoration of chronic-Delta 9-THC-induced decline in sexuality in male rats by a novel benzoflavone moiety from Passiflora incarnata Linn

Br J Pharmacol. 2003 Jan;138(1):117-20. doi: 10.1038/sj.bjp.0705015.

Abstract

1 The present study comprised treatment of healthy male rats with Delta(9)-tetrahydrocannabinol (THC, 10 mg kg(-1), p.o.), and combinations of THC with benzoflavone moiety (BZF, 10 and 20 mg kg(-1), p.o.) isolated from Passiflora incarnata Linneaus, over a period of 30 days. 2 Upon 30-days chronic administrations, the THC-treated male rats had a significant loss of libido (mounting behaviour with non-oestrous female rats), decrease in sperm count, and number of impregnated pro-estrous female rats. 3 Co-administration of BZF (10 and 20 mg kg(-1) p.o.) afforded significant protection against the chronic-THC-induced decrease in libido, mating performance and fertility during 30-day experimental regimen. The 20 mg kg(-1) dose of BZF exhibited better results. 4 Upon discontinuation of THC, treatment with BZF (10 and 20 mg kg(-1) p.o.) also facilitated the early restoration chronic-THC-induced decline in libido, sperm count and sexual fertility within 7 days.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzoflavones / pharmacology*
  • Dronabinol / adverse effects
  • Dronabinol / pharmacology*
  • Female
  • Male
  • Passiflora*
  • Plant Components, Aerial
  • Rats
  • Rats, Wistar
  • Sexual Behavior, Animal / drug effects*
  • Sexual Behavior, Animal / physiology
  • Sperm Count / statistics & numerical data

Substances

  • Benzoflavones
  • Dronabinol