Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 299 (5604), 245-7

Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice

Affiliations

Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice

R J Lucas et al. Science.

Abstract

In the mammalian retina, a small subset of retinal ganglion cells (RGCs) are intrinsically photosensitive, express the opsin-like protein melanopsin, and project to brain nuclei involved in non-image-forming visual functions such as pupillary light reflex and circadian photoentrainment. We report that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections were unchanged. These animals showed a pupillary light reflex indistinguishable from that of the wild type at low irradiances, but at high irradiances the reflex was incomplete, a pattern that suggests that the melanopsin-associated system and the classical rod/cone system are complementary in function.

Comment in

Similar articles

See all similar articles

Cited by 260 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback