Chemical shift correlation via RFDR: elimination of resonance offset effects

J Biomol NMR. 2002 Nov;24(3):237-43. doi: 10.1023/a:1021655316318.


It is shown that it is possible to effectively execute RFDR experiments with adiabatic inversion pulses and obtain resonance offset compensation that is superior to what can be achieved by conventional rectangular pulses. Employing 40-micros tanh/tan adiabatic pulses at a power level of approximately 38 kHz and a spinning speed of 12 kHz it is demonstrated that the range of resonance offset compensation achieved is sufficient to generate, via a single experiment, homonuclear chemical shift correlation spectra in the entire (13)C chemical shift range in peptides/proteins at the currently available field strengths.

MeSH terms

  • Amino Acids / chemistry
  • Carbon Isotopes / chemistry
  • Nuclear Magnetic Resonance, Biomolecular / methods*
  • Peptides / chemistry
  • Proteins / chemistry
  • Thermodynamics


  • Amino Acids
  • Carbon Isotopes
  • Peptides
  • Proteins