Nephrogenic fibrosing dermopathy (scleromyxedema-like illness of renal disease)

J Am Acad Dermatol. 2003 Jan;48(1):55-60. doi: 10.1067/mjd.2003.78.


Nephrogenic fibrosing dermopathy or scleromyxedema-like illness of renal disease is a recently reported disorder. It manifests as scleromyxedema-like skin lesions without associated paraproteinemia, occurring in the setting of renal disease. In the majority of cases skin lesions of nephrogenic fibrosing dermopathy develop after hemodialysis or renal transplantation; however, the origin is still unknown. We report 4 new cases of nephrogenic fibrosing dermopathy and review the literature. The clinical and histopathologic features, differential diagnosis, possible etiology, and treatment options are reviewed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Female
  • Fibrosis
  • Humans
  • Kidney Diseases / complications*
  • Male
  • Middle Aged
  • Myxedema / etiology
  • Skin Diseases / diagnosis
  • Skin Diseases / etiology*
  • Skin Diseases / pathology