Contact urticaria and anaphylactoid reaction induced by topical application of nitrogen mustard

Br J Dermatol. 1976 Jan;94(1):101-3. doi: 10.1111/j.1365-2133.1976.tb04350.x.


A 36-year-old woman and a 16-year-old boy, both suffering from mycosis fungoides, developed urticaria and an anaphylactoid reaction after topical whole body application of nitrogen mustard. Prick tests with nitrogen mustard solution produced a weal and flare response. Both patients had previously been treated intermittently with total body application of nitrogen mustard for 2 1/2 years and 1 year respectively without complications.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Anaphylaxis / chemically induced*
  • Humans
  • Male
  • Mechlorethamine / adverse effects*
  • Mechlorethamine / therapeutic use
  • Mycosis Fungoides / drug therapy
  • Urticaria / chemically induced*


  • Mechlorethamine