Multiple elements within the Xic regulate random X inactivation in mice

Semin Cell Dev Biol. 2003 Feb;14(1):85-92. doi: 10.1016/s1084-9521(02)00140-4.


In female mammals, the majority of the genes on one of the two X-chromosomes are silenced by a process referred to as X-chromosome inactivation. The X-inactivation center (Xic), a complex genomic region on the X-chromosome which controls this process, contains the Xist gene encoding an untranslated RNA which plays a central role in the establishment of the transcriptional repression. The Xic encrypts a sophisticated program which coordinates X inactivation with sex and embryonic development. The present article reviews our current knowledge of the regulatory elements lying within the mouse Xic and of the mechanisms underlying random X inactivation.

Publication types

  • Review

MeSH terms

  • Animals
  • Dosage Compensation, Genetic*
  • Female
  • Mice / genetics*
  • RNA, Long Noncoding
  • RNA, Untranslated / genetics
  • Transcription Factors / genetics


  • RNA, Long Noncoding
  • RNA, Untranslated
  • Transcription Factors
  • Tsix transcript, mouse
  • XIST non-coding RNA