Nanoparticle-mediated gene delivery to tumour neovasculature

Trends Mol Med. 2003 Jan;9(1):2-4. doi: 10.1016/s1471-4914(02)00004-7.


The alpha(v)beta(3) integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of alpha(v)beta(3)-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacology
  • Animals
  • Gene Transfer Techniques*
  • Humans
  • Integrin alphaVbeta3 / metabolism*
  • Models, Molecular
  • Nanotechnology
  • Neoplasms / blood supply*
  • Neoplasms / therapy*
  • Neovascularization, Pathologic*


  • Angiogenesis Inhibitors
  • Integrin alphaVbeta3