[Expression and clinical significance of collagenase-3 (MMP-13) in gastric cancer]

Gastroenterol Hepatol. 2003 Jan;26(1):1-7. doi: 10.1016/s0210-5705(03)70332-x.
[Article in Spanish]


Background: MMP-13 (collagenase-3) is a metalloproteinase with potent degradative activity against a variety of elements of the extracellular matrix. Its expression has been described in some human carcinomas, where it seems to play a role in tumor progression and metastasis. The objective of this study was to investigate the expression and clinical significance of MMP-13 in gastric carcinomas.

Patients and method: MMP-13 expression was analyzed by immunohistochemistry in resected specimens from 44 patients with gastric adenocarcinoma. The mean ( standard error) follow-up period was 21.4 3.2 months.

Results: A total of 14 gastric carcinomas (31.8%) showed positive immunostaining for MMP-13. The percentage of MMP-13-positive tumors was significantly (p = 0.009) higher in stage IV carcinomas (69.2%) than in lower stages (I: 22.2%; II: 12.5%; and III: 14.3%), as well as in nonresectable tumors (R1 and R2) (61.5%) than in resectable carcinomas (R0) (19.4%) (p = 0.017). Likewise, MMP-13 tumor expression was significantly associated with shortened overall survival in both the entire group of patients (p = 0.0006) and in the subgroup of patients with resectable tumors (p = 0.018).

Conclusions: Our results suggest that, in patients harboring gastric adenocarcinoma, MMP-13 tumor expression is associated with higher tumor aggressiveness and a poor prognosis.

Publication types

  • English Abstract

MeSH terms

  • Adenocarcinoma / enzymology*
  • Adenocarcinoma / mortality
  • Adenocarcinoma / pathology
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / analysis*
  • Collagenases / analysis*
  • Female
  • Follow-Up Studies
  • Humans
  • Life Tables
  • Male
  • Matrix Metalloproteinase 13
  • Middle Aged
  • Neoplasm Proteins / analysis*
  • Neoplasm Staging
  • Prognosis
  • Stomach Neoplasms / enzymology*
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery
  • Survival Analysis


  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Collagenases
  • MMP13 protein, human
  • Matrix Metalloproteinase 13