Pathways to Parkinsonism

Neuron. 2003 Jan 9;37(1):7-10. doi: 10.1016/s0896-6273(02)01166-2.


A novel gene for Parkinson's disease (PD), DJ-1, has been identified that encodes a multifunctional product with several known protein-protein interactions and effects on gene expression. Here, I outline how it is possible to construct hypotheses that place DJ-1 in different relationships to the other known PD genes, alpha-synuclein and parkin. The identification of multiple genetic causes will provide further impetus to describe the pathway leading to PD.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Mutation / genetics*
  • Oncogene Proteins / genetics*
  • Oncogene Proteins / metabolism
  • Oxidative Stress / genetics*
  • Parkinsonian Disorders / genetics*
  • Parkinsonian Disorders / metabolism
  • Parkinsonian Disorders / physiopathology
  • Protein Deglycase DJ-1
  • Protein Folding
  • Signal Transduction / genetics*


  • Intracellular Signaling Peptides and Proteins
  • Oncogene Proteins
  • PARK7 protein, human
  • Protein Deglycase DJ-1