Diversifying neural cells through order of birth and asymmetry of division

Neuron. 2003 Jan 9;37(1):11-4. doi: 10.1016/s0896-6273(02)01178-9.

Abstract

A key question in developmental neurobiology is how the diversity of cell types that make up the mature nervous system are generated from a common set of progenitor cells. Drosophila genes governing temporal cell fate determination and asymmetric cell divisions involving numb may represent evolutionarily conserved mechanisms for regulating cell fate diversification in the developing nervous system.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Cell Division / physiology*
  • Cell Lineage / physiology*
  • Drosophila Proteins
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / physiology
  • Humans
  • Juvenile Hormones / genetics
  • Juvenile Hormones / metabolism
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Nervous System / cytology
  • Nervous System / embryology*
  • Neurons / cytology*
  • Neurons / physiology
  • Stem Cells / cytology*
  • Stem Cells / physiology

Substances

  • Drosophila Proteins
  • Juvenile Hormones
  • Nerve Tissue Proteins
  • Numbl protein, mouse
  • numb protein, Drosophila