Controlling calcium entry

Cell. 2002 Dec 13;111(6):767-9. doi: 10.1016/s0092-8674(02)01197-2.


Ca(2+) enters cells through an assortment of Ca(2+)-permeable channels that respond to different stimuli and couple to different cellular responses. Several different Ca(2+) entry pathways can be activated by receptors that stimulate phospholipase C (PLC). Both limbs of this signaling pathway (IP(3) and diacylglycerol), PLC itself, and its substrate (PIP(2)) contribute to the coordinate regulation of these Ca(2+) entry pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Diglycerides / metabolism
  • Hydrolysis
  • Inositol 1,4,5-Trisphosphate / metabolism*
  • Membrane Potentials
  • Models, Biological
  • Neurons / metabolism
  • Phosphatidylinositol 4,5-Diphosphate / metabolism*
  • Protein Binding
  • Protein Structure, Tertiary
  • Signal Transduction
  • Type C Phospholipases / metabolism*


  • Diglycerides
  • Phosphatidylinositol 4,5-Diphosphate
  • Inositol 1,4,5-Trisphosphate
  • Type C Phospholipases
  • Calcium