Mapping cortical columnar structures using fMRI

Physiol Behav. 2002 Dec;77(4-5):641-4. doi: 10.1016/s0031-9384(02)00901-0.


Mapping cortical columnar structures is important to understand cortical information processing. To map submillimeter columnar structures noninvasively, we have evaluated various functional magnetic resonance imaging (fMRI) techniques using a well-established feline orientation column model. The conventional positive blood oxygenation level-dependent (BOLD) signal is widespread and diffuse due to large venous vessel contributions, resulting in its poor specificity to columns. However, the early-negative BOLD signal is induced by the early oxygen consumption increase without significant change in blood flow. This negative signal has been successfully applied for columnar mapping. Tissue-specific cerebral blood flow (CBF) response is also specific to individual cortical columns, suggesting that parenchyma-specific fMRI techniques are capable to map individual single-condition functional cortical columns in animals as well as humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antimetabolites
  • Brain Mapping*
  • Cats
  • Cerebral Cortex / physiology*
  • Cerebrovascular Circulation / physiology
  • Deoxyglucose
  • Female
  • Magnetic Resonance Imaging
  • Orientation / physiology
  • Oxygen Consumption / drug effects
  • Oxygen Consumption / physiology


  • Antimetabolites
  • Deoxyglucose