Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story

Immunol Lett. 2003 Jan 22;85(2):197-203. doi: 10.1016/s0165-2478(02)00231-6.


Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages; (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1; and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / metabolism
  • Bacterial Infections / immunology
  • Bacterial Infections / metabolism
  • Cation Transport Proteins / physiology*
  • Cations, Divalent / metabolism
  • Genetic Predisposition to Disease
  • Humans
  • Ion Transport
  • Iron / metabolism*
  • Macrophages / physiology*
  • Mice
  • Mice, Knockout
  • Promoter Regions, Genetic


  • Cation Transport Proteins
  • Cations, Divalent
  • natural resistance-associated macrophage protein 1
  • Iron