Arthropathy in juvenile hemochromatosis

Arthritis Rheum. 2003 Jan;48(1):227-30. doi: 10.1002/art.10755.


Objective: To evaluate whether arthropathy is associated with juvenile hemochromatosis and, if so, to assess the relationship between this feature and other clinical features of the disease.

Methods: Clinical, laboratory, and radiologic evidence of arthropathy was studied in 8 Greek patients with genetically proven juvenile hemochromatosis. Osteopenia and osteoporosis were assessed by bone mineral density measurement.

Results: Seven of the 8 patients had articular manifestations. The main affected joint was the metacarpophalangeal joint, and the arthritis was progressive independent of phlebotomy therapy. Osteopenia was observed in 2 patients, and osteoporosis in 2 patients.

Conclusion: Arthropathy may be present in patients with juvenile hemochromatosis, with features similar to those found in patients with hemochromatosis type 1.

MeSH terms

  • Adult
  • Age of Onset
  • Bone Density
  • Bone Diseases, Metabolic / diagnostic imaging
  • Bone Diseases, Metabolic / etiology*
  • Female
  • Ferritins / blood
  • Gonadal Steroid Hormones / blood
  • Hemochromatosis / complications*
  • Humans
  • Hypogonadism / complications
  • Male
  • Middle Aged
  • Osteoporosis / diagnostic imaging
  • Osteoporosis / etiology*
  • Radiography


  • Gonadal Steroid Hormones
  • Ferritins