TGF-beta signal transduction and mesangial cell fibrogenesis

Am J Physiol Renal Physiol. 2003 Feb;284(2):F243-52. doi: 10.1152/ajprenal.00300.2002.


Transforming growth factor-beta (TGF-beta) is closely associated with progressive renal fibrosis. Significant progress has been accomplished in determining the cellular signaling pathways that are activated by TGF-beta. This knowledge is being applied to glomerular mesangial cell models of extracellular matrix (ECM) accumulation. A central component of TGF-beta-stimulated mesangial cell fibrogenesis is the TGF-beta family-specific Smad signal transduction pathway. However, while Smads play an important role in collagen accumulation, recent findings indicate that cross talk among a variety of pathways is necessary for maximal stimulation of collagen expression. Further investigation of these multiple interactions will provide insight into possible ways to interrupt cellular mechanisms of glomerular fibrogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Fibrosis
  • Glomerular Mesangium / pathology*
  • Glomerulosclerosis, Focal Segmental / etiology*
  • Humans
  • Signal Transduction*
  • Transforming Growth Factor beta / metabolism*


  • Transforming Growth Factor beta