Creatine monohydrate in myotonic dystrophy: a double-blind, placebo-controlled clinical study

J Neurol. 2002 Dec;249(12):1717-22. doi: 10.1007/s00415-002-0923-x.


We assessed safety and efficacy of creatine monohydrate (Cr) in myotonic dystrophy (DM1) in a double-blind, cross-over trial. Thirty-four patients with defined DM1 were randomized to receive Cr and placebo for eight weeks (10.6 g day 1-10, 5.3 g day 11-56) in one of 2 treatment sequences. There was no significant improvement using manual and quantitative muscle strength, daily-life activities, and patients' own global assessment comparing verum with placebo administration. Cr supplementation was well tolerated without clinically relevant side effects, but did not result in significant improvement of muscle strength or daily-life activities.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living / psychology
  • Adult
  • Creatine / therapeutic use*
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle Weakness / drug therapy
  • Muscle Weakness / physiopathology
  • Muscle Weakness / psychology
  • Myotonic Dystrophy / drug therapy*
  • Myotonic Dystrophy / physiopathology
  • Myotonic Dystrophy / psychology
  • Statistics, Nonparametric


  • Creatine