Preterm premature rupture of the membranes and antioxidants: the free radical connection

J Perinat Med. 2002;30(6):447-57. doi: 10.1515/JPM.2002.071.


Aim: To discuss the role of oxidant stress in preterm, premature rupture of the membranes (PPROM).

Results: There is evidence to suggest that preterm, premature rupture of the membranes occurs secondary to focal collagen damage in the fetal membranes.

Conclusion: Oxidant stress caused by increased ROS formation and/or antioxidant depletion may disrupt collagen and cause premature membrane rupture. We propose that supplementation with vitamins C and E may synergistically protect the fetal membranes, and decrease the risks of PPROM.

Publication types

  • Review

MeSH terms

  • Antioxidants*
  • Dietary Supplements*
  • Female
  • Fetal Membranes, Premature Rupture / prevention & control*
  • Humans
  • Pregnancy
  • Vitamins*


  • Antioxidants
  • Vitamins