Correlation of urinary 1-hydroxypyrene and 2-naphthol with total suspended particulates in ambient air in municipal middle-school students in Korea

Arch Environ Health. Jul-Aug 2002;57(4):377-82. doi: 10.1080/00039890209601425.


The authors investigated Korean municipal middle school students to ascertain whether urinary 1-hydroxypyrene (1-OHP) and 2-naphthol-markers for polycyclic aromatic hydrocarbon (PAH) exposure-reflect PAHs in ambient air. The authors used the beta-ray absorption method, which is an index of ambient-air PAH exposure, to collect total suspended particulate (TSP) data. The authors measured urinary 1-OHP and 2-naphthol concentrations in 137 nonsmoking students in 4 municipal middle schools within 1 km of ambient air monitoring stations. The median concentrations of urinary 1-OHP and 2-naphthol in the study were 0.09 nmole/mol creatinine and 2.19 micromol/mol creatinine, respectively, and the geometric means were 0.10 nmole/mol creatinine and 2.47 micromol/mol creatinine, respectively. Urinary 1-OHP concentration did not correlate significantly with any TSP index. There were significant correlations between urinary 2-naphthol level and the daily mean TSP level calculated for 2 days before survey, for 1 day before survey, and for the day of survey. These data suggest that urinary 2-naphthol may be a good marker for inhalation exposure to PAHs in ambient air.

MeSH terms

  • Adolescent
  • Air Pollutants / adverse effects*
  • Air Pollutants / analysis
  • Biomarkers / analysis
  • Child
  • Female
  • Health Surveys
  • Humans
  • Inhalation Exposure*
  • Male
  • Mutagens / analysis*
  • Naphthols / urine*
  • Particle Size
  • Polycyclic Aromatic Hydrocarbons / adverse effects*
  • Polycyclic Aromatic Hydrocarbons / analysis
  • Pyrenes / analysis*
  • Regression Analysis
  • Students
  • Urinalysis


  • Air Pollutants
  • Biomarkers
  • Mutagens
  • Naphthols
  • Polycyclic Aromatic Hydrocarbons
  • Pyrenes
  • 1-hydroxypyrene
  • 2-naphthol