Selective cleavage of N-benzyl-protected secondary amines by triphosgene

Martin G Banwell; Mark J Coster; Michael J Harvey; John Moraes

doi:10.1021/jo0263622

Selective cleavage of N-benzyl-protected secondary amines by triphosgene

J Org Chem. 2003 Jan 24;68(2):613-6. doi: 10.1021/jo0263622.

Authors

Martin G Banwell¹, Mark J Coster, Michael J Harvey, John Moraes

Affiliation

¹ Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra ACT 0200, Australia. mgb@rsc.anu.edu.au

PMID: 12530894
DOI: 10.1021/jo0263622

Abstract

A series of competition experiments has revealed that selective cleavage of N-benzyl-protected secondary amines can be achieved with triphosgene, thereby providing a useful range of carbamoyl chlorides.