It is now accepted that investment in health is an important contributor to poverty reduction; however failure to immunise the world's children with readily available life-saving vaccines results in more than 3 million premature deaths annually. The Vaccine Fund-a new structural tool with a clear mission "every child every where" and the Global Alliance for Vaccines and Immunization (GAVI)-a true alliance of all global stakeholders, are working together to build sustainability of immunisation and immunisation capacity in the world's poorest countries.Substantial funding for immunisation has been raised but more is needed to complete the task of fully immunising the world's poorest children.