Plasma renin activity as a function of age in two new strains of spontaneously hypertensive and normotensive rats

Clin Sci Mol Med. 1976 Feb;50(2):103-7. doi: 10.1042/cs0500103.


1. Strains of spontaneously hypertensive and normotensive rats were selected by repeated inbreeding. 2. Brief ether anesthesia was shown to produce a two- to three-fold increase in plasma renin activity in both strains. 3. Plasma renin activity was significantly higher in young spontaneously hypertensive than in normotensive rats of the same age (5-7 weeks). After the ninth week plasma renin activity decreased and, at week 45, became significantly lower in hypertensive than in normotensive rats. 4. When hypertension was established a significant inverse relationship was found between plasma renin activity and systolic blood pressure in spontaneously hypertensive and in normotensive rats. 5. It seems unlikely that the renin-angiotensin system plays a major role in the maintenance of the established spontaneous hypertension in this strain. However, renin hypersecretion may be important in the early pre-hypertensive stage of genetic hypertension in rats.

MeSH terms

  • Aging
  • Anesthesia, General
  • Angiotensin II / blood
  • Animals
  • Body Weight
  • Ethyl Ethers
  • Hypertension / blood*
  • Male
  • Rats
  • Renin / blood*


  • Ethyl Ethers
  • Angiotensin II
  • Renin