Molecular analysis and pathology of a second pediatric HIV-associated Burkitt lymphoma

Pediatr Pathol Mol Med. 2002 Nov-Dec;21(6):525-30. doi: 10.1080/15227950290112770.


Diagnosis of a second HIV-associated non-Hodgkin lymphoma (HIV-NHL) is rare, but additional cases may occur as aggressive therapy for both HIV and NHL improves. An 11-year-old presented with a second primary HIV-NHL following remission for 9 years. Analysis of the tumor demonstrated presence of EBV and HIV with absence of CMV, HHV-8, and HHV-6. Although microscopic disease was present only in CSF, analysis of peripheral blood and bone marrow by PCR was positive. The patient underwent a stem cell transplant, but within 3 months, his disease recurred. Analysis for residual disease and viruses in similar cases may provide information in understanding pediatric HIV-NHL.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-HIV Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Burkitt Lymphoma / genetics*
  • Burkitt Lymphoma / pathology*
  • Burkitt Lymphoma / virology
  • Child
  • HIV / metabolism
  • HIV Infections / complications
  • Herpesvirus 4, Human / metabolism
  • Humans
  • Lymphatic Metastasis / pathology
  • Lymphoma, AIDS-Related / pathology
  • Male
  • Neoplasms, Second Primary / genetics
  • Neoplasms, Second Primary / pathology*
  • Neoplasms, Second Primary / virology
  • Polymerase Chain Reaction
  • Tomography, X-Ray Computed


  • Anti-HIV Agents