Abstract
During the course of our investigations in the field of azole antimicrobial agents, we have identified BM 212, a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 1-10 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Antibiotics, Antitubercular
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology
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Antitubercular Agents / pharmacology
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology
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Binding Sites
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Chemical Phenomena
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Chemistry, Physical
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Indicators and Reagents
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Isoniazid / pharmacology
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Conformation
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Morpholines / chemical synthesis*
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Morpholines / pharmacology*
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Mycobacterium / drug effects*
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Piperazines / chemistry*
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Piperazines / pharmacology*
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Pyrroles / chemical synthesis*
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Pyrroles / chemistry*
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Pyrroles / pharmacology*
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Rifampin / pharmacology
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Streptomycin / pharmacology
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antibiotics, Antitubercular
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Antifungal Agents
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Antitubercular Agents
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Antiviral Agents
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Indicators and Reagents
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Morpholines
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Piperazines
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Pyrroles
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BM 212
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Isoniazid
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Rifampin
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Streptomycin