Identifying immunotherapeutic targets for prostate carcinoma through the analysis of gene expression profiles

Ann N Y Acad Sci. 2002 Dec;975:232-46. doi: 10.1111/j.1749-6632.2002.tb05955.x.

Abstract

Carcinoma of the prostate represents one of the most frequently diagnosed cancers in men. If detected at an early stage, prostate cancer is highly treatable. However, cancers identified at a late stage are rarely cured with contemporary medical therapies. Early detection strategies presently center on the identification of prostate-specific proteins in the serum, and emerging therapeutics have utilized genes and proteins with prostate-restricted expression for tissue-selective immunological regimens incorporating vaccines, dendritic cell therapy, gene therapy, and antibody-based cell targeting. In order to develop improved therapeutic procedures, efforts have been directed toward the identification of genes exhibiting prostate-restricted expression profiles, or altered expression levels in neoplastic cells relative to their normal counterparts. Comprehensive expression profiling approaches such as the analysis of oligonucleotide- or complementary DNA (cDNA)-microarrays have greatly enhanced these efforts. Genes and their cognate proteins identified using such methods offer additional diagnostic and therapeutic targets that may aid in the understanding and treatment of prostate carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acid Phosphatase
  • Antigens, Surface*
  • Carboxypeptidases / immunology
  • Gene Expression Profiling
  • Glutamate Carboxypeptidase II
  • Humans
  • Immunotherapy* / methods
  • Male
  • Oligonucleotide Array Sequence Analysis
  • Prostate-Specific Antigen / immunology
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / immunology
  • Prostatic Neoplasms / therapy*
  • Protein Tyrosine Phosphatases / immunology
  • Testosterone Congeners / pharmacology

Substances

  • Antigens, Surface
  • Testosterone Congeners
  • Acid Phosphatase
  • prostatic acid phosphatase
  • Protein Tyrosine Phosphatases
  • Carboxypeptidases
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II
  • Prostate-Specific Antigen