Structure-activity relationships of cyclic acetylcholine analogues of the piperidinol and thiacyclohexanol series

Experientia. 1976 Mar 15;32(3):365-7. doi: 10.1007/BF01940841.

Abstract

The hydrochlorides and methiodides of 1-methyl-3- and 4-acetoxypiperidine and their sulphonium analogues are cholinergic agonists. They are substrates for acetylcholinesterase. The sulphonium compounds have a 78(-524)-fold higher activity than its nitrogen analogues.

MeSH terms

  • Acetylcholine / analogs & derivatives*
  • Animals
  • Cyclohexanols / pharmacology*
  • Guinea Pigs
  • Molecular Conformation
  • Muscle Contraction / drug effects
  • Muscle, Smooth / drug effects*
  • Piperidines / pharmacology*
  • Structure-Activity Relationship
  • Sulfonium Compounds / pharmacology

Substances

  • Cyclohexanols
  • Piperidines
  • Sulfonium Compounds
  • Acetylcholine