Abstract
The hydrochlorides and methiodides of 1-methyl-3- and 4-acetoxypiperidine and their sulphonium analogues are cholinergic agonists. They are substrates for acetylcholinesterase. The sulphonium compounds have a 78(-524)-fold higher activity than its nitrogen analogues.
MeSH terms
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Acetylcholine / analogs & derivatives*
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Animals
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Cyclohexanols / pharmacology*
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Guinea Pigs
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Molecular Conformation
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects*
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Piperidines / pharmacology*
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Structure-Activity Relationship
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Sulfonium Compounds / pharmacology
Substances
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Cyclohexanols
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Piperidines
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Sulfonium Compounds
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Acetylcholine