Leg muscle strength is reduced in Parkinson's disease and relates to the ability to rise from a chair

Mov Disord. 2003 Feb;18(2):157-62. doi: 10.1002/mds.10299.

Abstract

Individuals with Parkinson's disease (PD) have difficulties rising from a chair; however, factors contributing to this inability have never been investigated. We compared lower extremity strength between individuals with PD and healthy controls and quantified the relationships between strength and the ability to rise from a chair. Ten men with mild PD and 10 sex- and age-matched controls performed maximal concentric, isokinetic knee and hip extensor torque on an isokinetic dynamometer to quantify muscle strength. Subjects also rose from a chair at their comfortable pace without the use of their arms and the duration of this task provided a measure of sit-to-stand (STS) ability. Subjects with PD were tested in an on- and off-medication state on different days. Mean hip and knee extensor torques were lower in subjects with PD, with greater deficits found at the hip. Greater hip strength was related to better STS ability in subjects with PD while greater knee strength was related to better STS ability in controls. These results show that individuals with mild PD generate smaller extremity forces compared to controls. Reduced strength, particularly at the hip, may be one factor that contributes to the difficulty of persons with PD to rise from a chair.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiparkinson Agents / therapeutic use
  • Carbidopa / therapeutic use
  • Disability Evaluation
  • Drug Combinations
  • Female
  • Hip / physiopathology
  • Humans
  • Knee / physiopathology
  • Levodopa / therapeutic use
  • Lower Extremity / physiopathology*
  • Male
  • Middle Aged
  • Muscle Weakness / diagnosis
  • Muscle Weakness / etiology*
  • Muscle Weakness / physiopathology*
  • Muscle, Skeletal / physiopathology*
  • Parkinson Disease / complications*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / physiopathology*
  • Posture / physiology*
  • Random Allocation
  • Severity of Illness Index

Substances

  • Antiparkinson Agents
  • Drug Combinations
  • carbidopa, levodopa drug combination
  • Levodopa
  • Carbidopa