3'-Aminoadenosine-5'-uronamides: Discovery of the First Highly Selective Agonist at the Human Adenosine A3 Receptor

J Med Chem. 2003 Jan 30;46(3):353-5. doi: 10.1021/jm0255724.

Abstract

Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis*
  • Adenosine / chemistry
  • Adenosine / pharmacology
  • Amides / chemical synthesis
  • Amides / chemistry
  • Amides / pharmacology
  • Cell Line
  • Humans
  • Isoxazoles / chemical synthesis*
  • Isoxazoles / chemistry
  • Isoxazoles / pharmacology
  • Purinergic P1 Receptor Agonists*
  • Receptor, Adenosine A3
  • Structure-Activity Relationship

Substances

  • Amides
  • CP 608039
  • Isoxazoles
  • Purinergic P1 Receptor Agonists
  • Receptor, Adenosine A3
  • Adenosine