Controlling the Double Helix

Nature. 2003 Jan 23;421(6921):448-53. doi: 10.1038/nature01411.

Abstract

Chromatin is the complex of DNA and proteins in which the genetic material is packaged inside the cells of organisms with nuclei. Chromatin structure is dynamic and exerts profound control over gene expression and other fundamental cellular processes. Changes in its structure can be inherited by the next generation, independent of the DNA sequence itself.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / chemistry
  • Cell Nucleus / genetics
  • Chromatin / chemistry*
  • Chromatin / genetics
  • Chromatin / metabolism*
  • DNA / chemistry*
  • DNA / genetics
  • DNA / metabolism*
  • DNA Methylation
  • Gene Expression Regulation
  • Histones / chemistry
  • Histones / metabolism
  • Humans
  • Models, Molecular
  • Nucleic Acid Conformation*

Substances

  • Chromatin
  • Histones
  • DNA