The Drake Health Registry Study: findings from fifteen years of continuous bladder cancer screening

Am J Ind Med. 2003 Feb;43(2):142-8. doi: 10.1002/ajim.10166.


Background: The Drake Health Registry Study (DHRS) is an ongoing bladder cancer screening program initiated in 1986 due to workers' probable past exposure to the bladder carcinogen, beta-naphthylamine (BNA).

Methods: At periodic screening visits, a health survey is administered and three screening tests are applied to a urine sample, urinalysis (UA), papanicolaou (PAP), and quantitative fluorescence image analysis (QFIA). Positive screens are eligible for a free bladder cystoscopy with random biopsies.

Results: Forty of 51 persons eligible for diagnostic evaluation underwent cystoscopy. One person was diagnosed with carcinoma in situ, two with transitional cell papilloma, 14 with dysplasia, two of which developed transitional cell carcinoma; 26 had bladder abnormalities such as chronic inflammation, chronic cystitis, atypical changes, atypia, hyperplasia, or papillary clusters.

Conclusions: The DHRS continues to identify early stage bladder cancer and other abnormalities among workers exposed to BNA before 1981 and generates useful clinical, psycho-social, and epidemiologic data.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Naphthylamine / adverse effects*
  • Carcinogens / adverse effects*
  • Clinical Protocols
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Mass Screening / methods*
  • Mass Screening / statistics & numerical data
  • Middle Aged
  • Occupational Diseases / chemically induced
  • Occupational Diseases / diagnosis
  • Occupational Exposure / adverse effects
  • Pennsylvania
  • Registries*
  • Risk Factors
  • Sensitivity and Specificity
  • Surveys and Questionnaires
  • Urinary Bladder Neoplasms / chemically induced
  • Urinary Bladder Neoplasms / diagnosis*
  • Urinary Bladder Neoplasms / economics
  • Urinary Bladder Neoplasms / urine


  • Carcinogens
  • 2-Naphthylamine